Analisis Kemoterapi pada Pasien Tn. “AM” dengan Acute Lymphoblastic Leukaemia (ALL) disertai HIV Positif dan Hepatitis B

Leukemia Limfoblastik Akut (ALL/LLA) adalah proliferasi ganas sel limfoid yang tersumbat pada tahap awal diferensiasi dapat menyerang sumsum tulang, darah, dan situs ekstrameduler. Penatalaksanaan leukemia meliputi terapi kuratif suportif. Studi kasus ini bertujuan untuk memperoleh gambaran tentang regimen kemoterapi pasien ALL disertai Hepatitis B Kronik HIV positif. Pengumpulan data menggunakan desain deskriptif dengan metode wawancara serta observasi langsung kondisi e-rekam medik, e-resep dikaji kesesuaiannya berdasarkan protokol kemoterapi. Berdasarkan sequencing diperoleh bahwa menerima Hyper CVAD nilotinib, dimana penilaian resiko Chemotherapy Induced Nausea Vomiting diterima termasuk dalam kategori Moderate Emetogenic. Regimen juga pemberian Methotrexate dosis tinggi sebagai profilaksis CNS. Akan tetapi, mengurangi nefrotoksisitas akibat tinggi, maka diperlukan tambahan natrium bikarbonat allopurinol mencegah TLS ALL.Acute Lymphoblastic Leukaemia (ALL) is a malignant proliferation of lymphoid cells that are occlude at an early stage differentiation and can invade the bone marrow, blood, extramedullary sites. Management includes curative supportive therapy. This case study aims to obtain overview chemotherapy patients with chronic hepatitis HIV. Data were collected in descriptive design interview methods direct observation patient conditions e-medical records. E-prescriptions reviewed for suitability based on protocols. Based sequencing, it was found received hyper-CVAD while chemotherapy-induced nausea risk assessment protocol included Emetogenic category. also accompanied by administration high doses as CNS prophylaxis. However, reduce nephrotoxicity due Methotrexate, necessary add sodium bicarbonate prevent ALL.